3 research outputs found

    Romanian Harmonization of Laws with European Union Policies Regarding Consumer Protection

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    The consumer protection policy is more and more present at the core of the main challenges facing the citizens, the economy and societies and the need for consumer trust that would stimulate the economy, has never been greater (European Commission, 2007). Therefore, the European Union has been regulated guidelines aimed at consumer protection. These principles were incorporated in a common strategy of Member Community Strategy during 2007-2013 and provided for setting and actions to be taken at European Union level to achieve these objectives. In what follows, we present the basic ideas set out in the European Union Consumer Strategy and their transposition stage in our legislation in order to achieve full legislative harmonization.consumers, consumer protection, consumer protection policies, European Union policies, Romanian harmonization of laws

    Neurobehavioral and Ultrastructural Changes Induced by Phytosynthesized Silver-Nanoparticle Toxicity in an In Vivo Rat Model

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    (1) Background: The study aimed to assess neurobehavioral, ultrastructural, and biochemical changes induced by silver nanoparticles synthesized with Cornus mas L. extract (AgNPs-CM) in rat brains. (2) Methods: The study included 36 male adult rats divided into three groups. Over a period of 45 days, AgNPs-CM (0.8 and 1.5 mg/kg b.w.) were administered daily by gavage to two of the groups, while the control group received the vehicle used for AgNP. After treatment, OFT and EPM tests were conducted in order to assess neurobehavioral changes. Six of the animals from each group were sacrificed immediately after completion of treatment, while the remaining six were allowed to recuperate for an additional 15 days. Transmission electron microscopy (TEM), GFAP immunohistochemistry, and evaluation of TNFα, IL-6, MDA, and CAT activity were performed on the frontal cortex and hippocampus. (3) Results: Treated animals displayed a dose- and time-dependent increase in anxiety-like behavior and severe ultrastructural changes in neurons, astrocytes, and capillaries in both brain regions. Immunohistochemistry displayed astrogliosis with altered cell morphology. TNFα, IL-6, MDA, and CAT activity were significantly altered, depending on brain region and time post exposure. (4) Conclusions: AgNPs-CM induced neurobehavioral changes and severe cell lesions that continued to escalate after cessation of exposure
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